EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

INDUCTION OF GAMMA-INTERFERON: THE POSSIBILITY OF USING RIBOSOMAL AND MEMBRANE FRACTIONS OF BACTERIA AS A MITOGEN

Ismailova A. A., Adylov D. G., Kasimova M. S., Petrova T. A., Rozumbetov R. J., Saydaliev A. E., Akbarov U. S., Rakhimjonov A. A.*

ABSTRACT

The study of induced cytokine production is one of the important and developing aspects of establishing the immunological state of the organism in the modern world. But due to the inaccessibility of classical mitogens remains poorly understood. The aim of the study was to identify the possibility of using the complex of ribosomal and membrane fractions of the bacteria Klebsiella pneumoniae, Streptococcus pneumoniae, Streptococcus pyogenes and Haemophilus influenzae to induce the production of gamma-interferon. The results showed the possibility and feasibility of their use as a mitogen in patients with chronic viral hepatitis B and C.

Keywords: Gamma-interferon, induction, ribosomal and membrane fractions.

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