EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ACUTE ORAL TOXICITY AND ANTI TUSSIVE EFFECT OF K SYRUP (POLY HERBAL FORMULATION) ON SO2 INDUCED COUGH MODEL

Nilesh Patel, Dr. Janmejay Patel*, Achal Patel, Prof. Dr. Upendra U. Zala*

ABSTRACT

Introduction- The herbal drugs mentioned in classics for treatment of airway infections are better than modern drugs like anti-tussive, expectorants, mucolytics etc., as they have no side effect. Aim: To evaluate acute oral toxicity of K Syrup on Swiss Albino Mice and to evaluate anti tussive effect of K Syrup in SO2 induced cough in Mice. Method: The present study was conducted according to OECD guideline AOT-425 to know single dose toxicity of K-Syrup. The IAEC no of study is SKPCPER/IAEC/2016-02/02. The male and female animals were selected for study of 8 - 12 weeks old with weight range of within ± 20 % of mean body weight at the time of randomization. A limit dose of 2000 mg/kg of extract was used involving five mice. Each mouse was treated with a single oral dose of 2000 mg/kg of extract in sequence at 48 h intervals. Animals were observed individually at least once during the first 30 min after dosing, periodically during the first 24 h, and daily thereafter, for a total of 14 days for any clinical signs of toxicity or mortality. Body weight of all animals was recorded once in a week. The anti tussive effect was evaluated in SO2 induced cough model in mice by method as describe by Miyagoshi et al., 1986 with modified and simplified. Results: There were no physical and behavioral changes observed in swiss albino mice during 14 days. Body weight of all animals did not reveal any significant change as compared to vehicle control group. Mortality was not observed in any animal of a group. The test drug treated group shows significant decrease in cough bouts and greater % inhabitation of cough bouts which favors its potential anti tussive effect as compared to DC and Standard drug treated groups. Conclusion: This study reveals that K Syrup (Anti tussive polyherbal formulation) does not have any toxic effect at dose of 2000 mg/kg. So No-Observed-Adverse-Effect-Level (NOAEL) of K Syrup is 2000 mg/kg. The significant decrease in cough bouts proves potential anti tussive activity of K Syrup (Anti tussive polyherbal formulation).

Keywords: Anti tussive, Acute oral toxicity, K Syrup, Mortality, NOEL.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )