ROLE OF MR SPECTROSCOPY IN THE EVALUATION OF ADULT INTRACRANIAL NEOPLASMS
Dr. Nahas K. M.*, Dr. Ashok Kumar Y. G, Dr. Najah Mohamed Nizam and Dr. Abhinay A.
AIM: The aim of the study was to compare the efficacy of MR spectroscopy in predicting the histology of intracranial neoplasms and to correlate with WHO grading. METHODS AND MATERIALS: This prospective study was performed in 41 patients with intracranial tumours. The levels at TE 144ms and TE 35ms. were calculated within the tumor, the peritumoral region, and the contralateral normal appearing white matter .The ratios were calculated by dividing the maximum value in the tumor and in the peritumoral region by the value in the contralateral normal-appearing white matter. For statistical analysis Student independent t-test and ROC curve analysis was performed. RESULTS: The difference in the mean Cho/Cr, Cho/Naa and Lip/Lac ratios of high and low grade gliomas were statistically significant. Among all the parameters Cho/Cr was the best parameter to identify high-grade gliomas, >2.554 for Ch/Crt yielded 87.5 % sensitivity and 90 % specificity and a cut off of >1.595 for Ch/Crp yielded 87.5 % sensitivity and 90 % specificity.Similarly the difference in the mean Cho/Cr, Cho/Naa of high grade glioma and metastasis were statistically significant. Among all parameters identify high-grade gliomas, a cut off of > 1.53 for Ch/Crp yielded 87.5 % sensitivity and 77.8 % specificity. CONCLUSION: MRI spectroscopy showed very good diagnostic accuracy in grading glial tumors, as well as in the differentiation of GBM from metastasis.
Keywords: Glioma Magnetic resonance imaging Spectroscopy Tumour.
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