EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ROLE OF MR SPECTROSCOPY IN THE EVALUATION OF ADULT INTRACRANIAL NEOPLASMS

Dr. Nahas K. M.*, Dr. Ashok Kumar Y. G, Dr. Najah Mohamed Nizam and Dr. Abhinay A.

ABSTRACT

AIM: The aim of the study was to compare the efficacy of MR spectroscopy in predicting the histology of intracranial neoplasms and to correlate with WHO grading. METHODS AND MATERIALS: This prospective study was performed in 41 patients with intracranial tumours. The levels at TE 144ms and TE 35ms. were calculated within the tumor, the peritumoral region, and the contralateral normal appearing white matter .The ratios were calculated by dividing the maximum value in the tumor and in the peritumoral region by the value in the contralateral normal-appearing white matter. For statistical analysis Student independent t-test and ROC curve analysis was performed. RESULTS: The difference in the mean Cho/Cr, Cho/Naa and Lip/Lac ratios of high and low grade gliomas were statistically significant. Among all the parameters Cho/Cr was the best parameter to identify high-grade gliomas, >2.554 for Ch/Crt yielded 87.5 % sensitivity and 90 % specificity and a cut off of >1.595 for Ch/Crp yielded 87.5 % sensitivity and 90 % specificity.Similarly the difference in the mean Cho/Cr, Cho/Naa of high grade glioma and metastasis were statistically significant. Among all parameters identify high-grade gliomas, a cut off of > 1.53 for Ch/Crp yielded 87.5 % sensitivity and 77.8 % specificity. CONCLUSION: MRI spectroscopy showed very good diagnostic accuracy in grading glial tumors, as well as in the differentiation of GBM from metastasis.

Keywords: Glioma Magnetic resonance imaging Spectroscopy Tumour.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database