EFFECTIVENESS OF IMMUNO-CORRECTING THERAPY IN CHILDREN IN THE COMPLEX TREATMENT OF CHRONIC BRONCHITIS

Dilorom Abdullayevna Musakhodjaeva, Fayzullaeva Nigora Yakhyaevna and *Sultanov Zakhiriddin Fakhriddinovich

ABSTRACT

Background: The frequency of respiratory diseases remains one of the urgent problems of modern pediatrics, determining the high level of childhood morbidity, infant mortality, and disability in adolescence. Objective: We examined 55 children aged 4 to 7 years with chronic bronchitis. Methods: The concentration of cytokines IL-1ß, IL-4, TNF-α in the blood serum was determined by enzyme-linked immunosorbent assay in the dynamics of treatment with the inclusion of immunocorrective drugs Bioflazid and Ribomunil. Result: It was found that the initial level of TNFα and IFNγ in sick children was significantly higher, and the level of IFNγ was significantly lower than the values of the control group. Sick children comprised 2 groups: group 1 — 25 children, in whose traditional treatment the drug Bioflazid was connected; Group 2 - 30 children, to the traditional treatment of which Bioflazid and Ribomunil were connected. Conclusion: It is shown that the inclusion in the complex therapy of drugs with immunocorrective effect contributes to the positive dynamics of clinical and immunological parameters.

Keywords: chronic bronchitis, cytokines, immunocorrection, Bioflazid, Ribomunil.