ELECTROCHEMICAL BEHAVIOR OF ANTICANCER CHALCONE DERIVATIVES ON GLASSY CARBON ELECTRODE

Dr. Shivaraj Yellappa* and Mallappa M.

ABSTRACT

The electrochemical behavior of anticancer chalcone and its derivates was studied at a glassy carbon electrode using cyclic and differential-pulse voltammetric techniques. At the bare glassy carbon electrode (GCE), the anticancer chalcone and its derivates were shown to be single well defined irreversible cathodic peak at -1.48 V in methanol containing 0.1 M TBAP with scan rate 50 mV/s and the electrode reaction process is found to be diffusion controlled. The various parameters such as effects of anodic peak potential (Ep), anodic peak current (Ipa), scan rate, effect of substituent, heterogeneous rate constant (k0), etc have been discussed. The shifts in peak potential were observed with the various in substituents.

Keywords: Chalcone derivatives, voltammetry, glassy carbon electrode,