SYNTHESIS OF ORGANOTIN POLY(AMINE ETHERS) FROM THE HIV DRUG LAMIVUDINE (3TC)
Francesca Mosca, Charles E. Carraher Jr.,* Michael R. Roner, Paul Slawek, Alisa Moric-Johnson, Lindsey C. Miller and Jerome E. Haky
Organotin poly(amine ethers) were rapidly synthesized in good yield employing the interfacial polycondensation
system. Yield increases as the size of the alkyl group on the tin increases. Synthesis employed commercially
available reactants allowing for ready production in gram to kilogram quantities. Infrared spectroscopy showed the
formation of new bands characteristic of the Sn-O- and Sn-N linkages. MALDI MS shows ion fragment clusters to
nine and ten units in length. The polymers exhibit decent inhibition of all of the tested human cancer cell lines
including two human pancreatic, two human breast and two human glioblastoma brain cancer cell lines.
Keywords: Organotin poly(amine ethers); HIV; lamivudine; MALDI MS; interfacial polymerization; pancreatic cancer; breast cancer; cancer; brain cancer; glioblastoma inhibition.
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