EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

TRANSUNGUAL DRUG DELIVERY SYSTEM FOR TREATMENT OF ONCOMYSIS: DESIGN AND DEVELOPMENT

Mayur Patil*, Dipali Bhondwe, Parag Potbhare, Nagesh Debgunde, Saroja Adepawar

ABSTRACT

Objective: The present study focuses on development and evaluation of transungual drug delivery system (TDDS) of Luliconazole (LNZ) for treatment of oncomysis. Method: The antifungal nail lacquer formulations of batches (F1-F4) were prepared by simple mixing method by using 1% w/w LNZ used as drug, nitrocellulose used as film former, glycerine used as viscosity modifier and thioglycolic acid and urea-H2O2 solution used as permeation enhancer. Effect of permeation enhancer was studied. Properties for its nonvolatile content, drying time, gloss, smoothness to flow, blush effect, in vitro adhesion, water resistance, in vitro drug release, drug content, in vitro antifungal studies and stability studies were carried out. Results: The prepared formulations (F1- F4) showed required volatile content, good film formation, drying time, smooth flow and high water resistance, none of the formulation exhibited blistering or peeling off, good adhesive properties. Drug release studies showed prolonged drug release up to 8 hr. The effective zones of inhibitions suggested that LNZ nail lacquer exhibiting good antifungal activity. Stability study revealed that no significant change with respect to the evaluations. Conclusion: The prepared transungual drug delivery system has proved to be a promising carrier system for the treatment of oncomysis.

Keywords: Luliconazole, Transungual drug delivery, Permeation enhancer, Oncomysis.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )