EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

A COMPARATIVE STUDY OF ORAL TRAMADOL AND BUPRENORPHINE TRANSDERMAL PATCH FOR PAIN CONTROL FOLLOWING REMOVAL OF MANDIBULAR IMPACTED THIRD MOLARS

Dayanithi B. S., Titus Thomas K., Neelakandan R. S. and Karthik L.*

ABSTRACT

Objective: To evaluate the efficacy of oral tramadol and transdermal buprenorphine patch in postoperative pain management of patients following the bilaterally mesioangular impaction. Materials and Methods: The present study included 22 healthy subjects underwent surgical removal of impacted mandibular third molars. The surgical procedure was performed under local anaesthesia by administering an inferior alveolar nerve block with a minimum interval of 1 week in-between the procedures. The postoperative pain was recorded on four subjective scales where readings were taken at various time intervals viz., 2, 6, 10 AM and 2, 6, 10 PM. The same procedure was repeated on the subsequent 2nd and 3rd day and readings were recorded for a total of 3 days. After performing the surgery on one side all the patients received oral tramadol 50 mg twice daily for 3 days. When the same patients returned a week later, they were administered transdermal buprenorphine patch once for duration of 3 days on the contralateral side. Results: From the statistical analysis and clinical observation, it was found that on the first postoperative day transdermal buprenorphine possessed statistical significance when compared to oral tramadol. However, on the subsequent two days of administration no statistical difference was observed in the pain control by either route of administration. Conclusion: The results were in favour of transdermal buprenorphine patches over oral tramadol tablets; suggesting that the buprenorphine patches were not inferior to the oral tramadol tablets, and that both products provided statistical and clinically significant reduction in pain.

Keywords: Dental pain; Tramadol; Transdermal patch; Mandibular Molars.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )