EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

FABRICATION AND CHARACTERIZATION OF ACECLOFENAC SODIUM LOADED LIPOSOMAL GEL

Chandrashekhar Vishnu Babar*, Amar Shripati Kulkarni and Samar Rangrao Patil

ABSTRACT

An attempt was made to formulate and characterize liposomal gel of aceclofenac sodium as a model drug using carbopol 934 as gelling agent with a view to deliver drug at controlled/sustained manner through transdermal route and consequently into systemic circulation. The “Homogenization techniques” was adopted for preparation of Aceclofenac loaded liposomal gel. For preparation of liposomal loaded Aceclofenac sodium 32 factorial design was used where the concentration of soya lecithin and cholesterol is varied at three different levels. Aceclofenac sodium shows maximum absorption at wavelength 274nm in 7.0 pH phosphate buffer using UV spectrophotometer. Standard calibration curve obeyed Beer's law at given concentration range of 2 μg/ml to 10 μg/ml. The value of regression coefficient was found to be 0.9993, which showed linear relationship between concentration and absorbance. The physical mixture of drug with polymer gave peaks which corresponded to the parent peaks of the pure drug which confirmed the compatibility between drug and polymer. In the DSC study indicates compatibility between drug and polymer. Physicochemical parameters such as drug content, percentage yield, SEM, DSC were carried out. The prepared liposomes exhibited satisfactory physical characteristics.The obtained liposomal gels were found to be three dimensional networks like structure and drug content 75.95% to 89.03%. Viscosity analysis indicating increase in soya lecithin and cholesterol concentration increases the viscosity of the formulation. All the liposomal gel formulations were stable and good sustained release of the drug for a period of 12 hours. This implies that developed formulations have a potential to deliver the drug in controlled/ sustained release manner.

Keywords: Aceclofenac sodium, Gelling agent, Liposomes, Topical dosage form, controlled drug release.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )