ROLE OF FREE FATTY ACID AND ELEVATED VLDL IN TYPE II DIABETES MELLITUS -A REVIEW

Mohd Wamique*, WahidAli, S. Nishat Fatima Rizvi

ABSTRACT

Diabetes is associated with abnormalities in plasma lipid and lipoproteins. Each of these dyslipidemia is associated with elevated Low density lipoprotein cholesterol(LDL-C) and impaired clearence of VLDL and reduced plasma HDL levels. Defects in insulin production and hyperglycemia causes change in plasma lipoproteins in patient with diabetes. obesity and insulin resistant also lead to lipid abnormalities. In diabetic ketoacidosis elevation in VLDL have been recognized in which insulin concentration are low. Increase in hepatic lipase activity also contribute to decreased HDL concentration.Thus changes in hepatic lipase and lipoprotein may result in decrease HDL. Although many factors play a role and there is evidence that abnormalities in serum lipids and lipid metabolism are risk factors for increased evidence of CHD in type 2 diabetes mellitus.

Keywords: Diabetes, VLDL, Triglycerides, HDL, Lipoproteins.