EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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Abstract

EVALUATION OF ANTHELMENTIC ACTIVITY OF CROSSANDRA INFUNDIBULIFORMIS FLOWERS

T. Panduraju*, V. Tejomayee, V. Nandini and G. Bhaskar

ABSTRACT

Helminthiasis is the most common infection caused by macro parasitic worms that is contaminant to human body parts. An anthelmintic drug can act by causing paralysis of the worm, or by damaging its cuticle, which lead to partial digestion or rejection by immune mechanisms. Most of the existing synthetic anthelmintic drugs produce serious adverse effects. In order to eliminate the harmful side effects of these synthetic anthelmintic drugs, it is important for us to promote the studies of traditionally used anthelmintic plant based drugs. The aqueous flower extract of Crossandra infundibuliformis was prepared with distilled water by maceration method. The aqueous flower extract is used to evaluate the presence of phytoconstituents and anthelmintic activity. The phytoconstituents like carbohydrates, glycosides, alkaloids, tannins, saponins and flavonoids were observed in the extract. The anthelmintic activity was investigated on Indian earth worm (Pheritima posthuma). Anthelmintic activity was performed in three different concentrations such as 20 mg/ml, 50 mg/ml and 100 mg/ml. Albendazole (10 mg/ml) was used as reference standard drug whereas distilled water as control. Determination of paralysis time and death time of the worms were recorded. Extract exhibited more significant anthelmintic activity at the concentration of 100 mg/ml. The results reported in the present work shows evidence that the flower of Crossandra infundibuliformis possess anthelmintic activity. Therefore, further study must be carried out so that the general people can get actual benefits from important medicinal plants like Crossandra infundibuliformis.

Keywords: Crossandra infundibuliformis, Anthelmintic activity, Pheritima posthuma, Albendazole.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia