FORMULATION APPROACH FOR MUCOADHESIVE BIO-FLEXY STRIPS OF NANOSIZED BROMOCRIPTINE FOR ORO-TRANS LABIAL DRUG DELIVERY PLATFORM

*Vishakha Jaiswal and Prof. (Dr.) N.V. Satheesh Madhav

ABSTRACT

The aim of the current research was to formulate mucoadhesive flexy strips loaded with bromocriptine and evaluate its performance. Mucoadhesion can significantly improve systemic as well as targeted therapeutics. The oral bioavailability of bromocriptine is only 6%. Nanoparticulate form of bromocriptine was achieved by Novel method using 1,2,3-Propanetriol as nanosizant. Ten formulations (FAO1-FAO5 and FG1-FG5) having different ratios (1:1, 1:2, 1:3, 1:4 and 1:5) of biopolymer from Anacardium occidentale and Guargum were prepared by „solvent casting method‟. All the formulations were subjected to various evaluation parameters like appearance, thickness, surface pH, weight uniformity, content uniformity, folding endurance and in-vitro release study. All the strips were flexible, smooth and translucent in appearance. The thickness of all strips were in the range of 01mm to 02mm. Surface pH of all strips were in the range of 7.31 to 7.38. In-vitro release kinetics was performed using Franz Diffusion Cell apparatus and analyzed through BIT-SOFT 1.12. Formulation FAO4 was selected as the best formulation on the basis of different evaluation parameters and it followed Higuchi Matrix model with R2 value 0.9463. The research work concluded that bio-flexy strips can be promising mucoadhesive dosage form for delivery of bromocriptine.

Keywords: Bromocriptine, Nanosizing, Mucoadhesive, Anacardium occidentale, Biopolymer.