EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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Abstract

CARDIAC AND HEPATIC TOXICITY IN PARAPHENYLENE DIAMINE (HAIR DYE) POISONING AMONG SUDANESE

Ahmed A. Mohammed*, Mohammed A. Elkablawy, Hitham Abdelgodoos, Abdelkadir Albasri and Ishag Adam.

ABSTRACT

Accidental and deliberate PDD poisoning is not uncommon. The toxic effects of the dye on kidneys, liver and muscles are not fully understood and the cardiac toxicity is far poorly understood and ignored. A prospective descriptive cross sectional study was conducted in ENT hospital, Khartoum , Sudan to investigate the level of troponin, CKMB, CKtotal, LDH, AST, ALT and myoglobin in patients presented with parapheneylene diamine poisoning. A total of 40 patients were investigated. Levels were measured according to manufacturer protocols and normal values were taken accordingly. Among the study population the majority were females38 (95%) in the age group more than 32 years. The presenting symptoms were laryngeal edema, neck swelling and muscular swelling, the main presenting symptom was neck swelling which was found in 22.5% of the population. There were 24 patients (40%) having no symptoms. The average values for troponin, CKMB, CKtotal, myoglobin, LDH, AST and ALT were found to be 0.018 (ng/ml), 566.8 (U/L), 1775 (U/L), 404.4 (ng/ml), 1800.5 (U/L), 636 (IU/L) and 305.4 (IU/L) consecutively. Troponin was found to be increased in 10% of the pateints, where lower reading was found to be 0.021 (ng/ml) and upper reading was 0.05 (ng/ml) normal value was taken up to 0.014. Thus in this study cardiac rhabdomyolysis in parapheneylene diamine poisoning was documented, the findings were not correlated with plasma level of the dye.

Keywords: cardiac rhabdomyolysis, parapheneylene diamine (PPD) poisoning, Sudan.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia