EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

DEVLOPMENT AND VALIDATION OF UV-SPECTROPHOTOMETRIC AND HPLC METHOD FOR APREMILAST IN BULK AND TABLET DOSAGE FORM

Hemaraj R. Patil*, Dr. S. T. Patil, V. H. Jain and Dr. S. P. Pawar

ABSTRACT

The aim of this research work was to develop simple, precise and rapid UV-Spectrophotometric and HPLC methods for analysis of Apremilast in Bulk and Tablet dosage form. UV-Spectrophotometric method was developed for the estimation of Apremilast in individual tablet dosage form. The proposed methods were applied for the determination of drugs in bulk and tablet dosage form. Determination of Apremilast was done by simple method. In this method, concentration was obtained by using the absorptivity values calculated for the drugs at wavelengths, 230 nm. A rapid and reliable HPLC method was developed and validated for estimation of Apremilast in bulk and tablet dosage form. Chromatographic separation was performed on Agilent C 18 (4.6 mm 250 mm i.d.), 5μm particle size in isocratic mode, using a mobile phase Acetonitrile: Water (70:30 v/v), pH 7. The retention time for Apremilast was found to be 4.92 min. The method was applied to marketed tablet formulations. The UV-Spectrophotometric method was found to be simple, economical and rapid as compared to HPLC. But, HPLC method was found to be more accurate, precise, robust and rugged. Both these methods can be used for routine analysis of Apremilast in Bulk and Tablet dosage form.

Keywords: Apremilast, UV-Spectrophotometric, HPLC.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia