REVIEW ON BI-LAYER TABLET: AN EMERGING TREND
Sudarshan B. Kakad* and Dr. Punit R. Rachh
Controlled release dosage form is a term used to describe the dosage forms having drug release features based on
the time, course and/or location and which are designed to accomplish therapeutic or convenience objectives which
are not offered by conventional release dosage forms. Whereas immediate release drug delivery system is intended
to disintegrate rapidly and exhibits instant drug release. However, it is also associated with fluctuations in drug
plasma levels, which leads to reduction or loss in drug effectiveness or increased incidence of side-effects.
Therefore, to compensate the dip in drug plasma concentration due to metabolism and excretion, it is necessary to
administrate the dosage form several times per day. Bilayer tablet is the novel technology for the development of
immediate release and controlled release formulation. Developing a combination of two or more active
pharmaceutical ingredients in a single dosage form is known as a bilayer tablet. It is more suitable for gradual
release of two active ingredients in combination. This technology is an excellent improved technique for providing
combine release pattern of drug i.e. immediate release and sustained release or two different categories. The
present review focuses on formulation and evaluation aspects of bilayer tablets.
Keywords: Bilayer tablet, controlled release, immediate release etc.
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