EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

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 ICV - 79.57

Abstract

GASTROPROTECTIVE EFFECT OF THE COMBINED AQUEOUS EXTRACT OF OCIMUM GRATISSIMUM AND CHROMOLAENA ODORATA ON EXPERIMENTALLY INDUCED PEPTIC ULCER IN WISTAR RATS

Cyril Agbor*

ABSTRACT

The effect of the combined extracts Chromolaena odorata and Ocimum gratissimum leaves on duodenal ulcer was evaluated by using the ethanol induced ulcer model. Twenty adult albino wistar rats of either sex weighing between 100 and 150 g were randomly allotted into five groups with four animals each: Normal control, ulcer control, Low dose (250mg/kg), High dose (500mg/kg) and Omeprazole (30mg/kg). The low and high doses of the combined extracts were administered once daily for 14 days. After treatment, the animals were fasted for 24 hours and gastric lesions were induced by the administration of 80% ethanol via oral intubation 60 minutes before sacrifice. Sections of the duodenal tissue of the rats were excised for histopathologic analysis using light microscopy to assess gastric mucosal lesions, presence of necrosis, and degree of inflammation. Pre-treatment with the combined extracts reduced the formation of duodenal lesions in a dose dependent manner. The standard reference drug also exhibited some inhibition of ulcer from ethanol. The results obtained, provides evidence of gastro-protective activity of the combined leaf extract of Chromolaena odorata and Ocimum gratissimum and supports the traditional use of these plants for the treatment of ulcer.

Keywords: Duodenal ulcer, Chromolaena odorata and Ocimum gratissimum leaves, Gastro-protection.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia