EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ANTI-INFLAMMATORY AND ANTIOXIDANT EFFECTS OF THE STEM BARK AQUEOUS EXTRACT OF RAUWOLFIA VOMITORIA (APOCYNACEAE) IN FEMALE WISTAR RATS

Youmbie Djanche Duplex Bonheur*, Dzeufiet Djomeni Paul Désiré, Nkwengoua Zondegoumba Ernestine, Zingue Stéphane5, Mezui Christophe, Bibi Farouck Aboubakar Oumarou, Tankeu Nzufo Francine, Pieme Constant Anatole, Dimo Théophile*

ABSTRACT

Rauwolfia vomitoria is widely used in African traditional medical practice in the treatment of several inflammatory-related disorders. Since, several studies have suggested that the etiology of inflammation can partly be explained by oxidative stress, this study was directed to evaluate the anti-inflammatory and antioxydant effects of the stem bark aqueous extract of Rauwolfia vomitoria in female Wistar rats. In sub-chronic study, cotton pellet and carrageenan induced granuloma as well as formalin induced paw oedema models were used to evaluate the anti-inflammatory potential of the plant extract. For the chronic model, we assessed the effect of the extract against Complete Freund’s Adjuvant (CFA) induced inflammation. Administration of the aqueous extract (300 mg/kg) significantly reduced the formation of humid (31.25%) and dry (28.49%) granuloma in cotton pellet method compared with control. At the same dose, the plant extract also exhibited a significant sub-chronic anti-inflammatory effect by decreasing exudate volume (38.46%) and leukocytes number (53.68%) in air pouch test, and by reducing the paw oedema (49.60%) induced by formalin. Daily oral administration of the extract (300 mg/kg) or dexamethasone (1 mg/kg) for 10 and 12 days significantly inhibited by 55.98% and by 74.41% the paw eodema induced by formalin and CFA respectively when compared to control groups. CFA used alone significantly decreased reduced glutathione (GSH) level as well as superoxide dismutase (SOD) and catalase (CAT) activities in liver, kidney and spleen when compared to normal rats. Treatment with Rauwolfia vomitoria extract and dexamethasone significantly restored GSH, SOD and CAT in all investigated tissues. In addition, the plant extract significantly restored malondialdehyde (MDA), protein and nitrite concentrations in serum and tissues (liver, spleen and kidney) by reducing their content, as compared to CFA control group. Keeping in this view, the data suggest that Rauwolfia vomitoria aqueous extract may possess anti-inflammatory and antioxidant effects.

Keywords: Rauwolfia vomitoria, inflammation, Complete Freund’s Adjuvant, anti-oxidant, granuloma.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )