( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57



A. Vinod Kuamr*, T. Malyadri and P. Sreenivasaprasana


Atorvastatinis water insoluble drug commonly used in the treatment of hypercholesterolemia and dyslipidemia. The objective of the present investigation was to develop Atorvastatin spherical agglomerates to improve its solubility and dissolution characteristics by spherical crystllisation method. Methods: In preparation of Atorvastatin spherical agglomerates crystallization media used were methanol, water, and chloroform as bridging liquid and PVP K-30 as a polymer. The process variables such as amount and type of (bridging liquid and polymer), stirring speed, and stirring time were optimized. The spherical agglomerates were characterized by suitable analytical techniques and further subjected for determination of % drug content, particle shape analysis, solubility, and dissolution rate. The spherical agglomerates of the optimized batch were directly compressed into tablet; the dissolution profile of prepared tablet was compared with dissolution profile of marketed tablet. Result: The spherical agglomerates obtained with methanol (7 ml), water (50 ml), chloroform (1.5 ml), and PVP K-30 (0.5%) at 500 rpm and 15 minutes stirring time showed significant improvement in solubility and dissolution from a value of 0.029 mg/ml and 25.53% for pure Atorvastatin to 6.42 mg/ml and 91.31% of spherical agglomerate, respectively. The Atorvastatin tablet obtained with spherical agglomerates showed 89.65% cumulative drug release as compare to 80.28% of marketed tablet. Conclusion: A significant result obtained with the study indicates that spherical crystallization by spherical agglomeration technique can successfully be further explored and employed to improve solubility and dissolution characteristic of poorly soluble drugs.

Keywords: Atorvastatin, Spherical Crystallisation, Solubility, Hypolipedemic agent.

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia