EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

BILAYER TABLET TECHNOLOGY: A CONCISE REVIEW

Devender Chauhan and Dr. Dinesh Kaushik*

ABSTRACT

Bi-layer tablet is a new era for successful development of controlled release formulation along with several features to provide successful drug delivery. Bilayer tablet in the last few decade had developed an interest in developing a combination of two or more active pharmaceutical ingredients in a single dosage form which promotes patient compliance and Elegance to product. Bi-layer tablet is suitable for release of two drugs in combination in which one Layer is immediate release as initial dose and second layer is loading dose. Bi layer tablets are an effective drug delivery system for the treatment of analgesic, hypertension and diabetes because in these diseases combination therapies are often used. Bilayer tablet is beneficial technology to overcome the shortcoming of the single layered tablet. This review explains the therapeutic advantages of bilayer tablet by releasing the medicaments for the immediate relief and then maintaining the level of medicament for the certain time in order to get the sustain release of drug. Several pharmaceutical companies are currently developing bi-layer tablets due to various reasons; reduce frequency, patient compliance, therapeutic benefits and reduces cost of treatment. To reduce capital investment, quite often existing but modified tablet presses are used to develop such type of tablets. This article explains the latest development and production of quality bilayer tablets by overcoming common problems, such as layer separation, insufficient hardness, cross contamination between the layers, inaccurate individual layer weight control, reduced yield etc. Bilayer tablet have been controlled release in order to prevent undesirable side effects.

Keywords: Bilayer tablet, chemical incompatibilities, Elegance, Frequency.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia