( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57



Dr. Rahul Khobragade and *Dr. Uma A. Bhosale


Background: Dyslipidemia co-exist in majority of hypertensives reasoning potential risk of cardiovascular diseases (CVD). The risk of hypertension (HTN) increases with an impaired lipid profile. Statins offer significant clinical benefit in these patients preventing primary and secondary CVD and thus used as an adjuvant therapy. However statins on their own can cause certain side effects viz. diabetes, hematological, renal and hepatotoxicity which remained unendorsed due to combination therapy. Objective: This study was therefore conducted to reveal harmful effects adjuvant statin therapy in HTN patients on ACE-Inhibitors, as reported negligible interaction with statins unlike other anti-hypertensives. Methods: In this prospective cohort study hypertensives (30-70 yrs) of either sex taking ACE-Inhibitors were included. Patients were grouped into control (ACE-Inhibitors) and test groups (ACE-Inhibitors + statin <1 month) with reference to treatment they received. The detrimental effects of statins on various organ systems (heart, kidney & liver), biochemical and hematological parameters were assessed and compared after 6 months; gender and age specific adverse events were also studied. Data obtained was analyzed using student‟s„t‟-test of OpenEpi statistical software. Results: Study clearly revealed that statins exhibit significant increase in toxicity markers viz. blood sugar, liver enzymes (p<0.01), urea and creatinine (p<0.05, p<0.01), creatine phosphokinase (p<0.05) when compared to baseline and control. Conclusions: Statins are not as safe as they are portrayed by various researchers and they themselves may cause certain adverse effects for which physicians should be more aware and cautious while prescribing.

Keywords: Statins BSL KFT LFT CPK-MB.

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  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 July 2024 Issue has been Published, Kindly check it on


    JULY 2024 issue has been successfully launched on JULY 2024.

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    EJPMR Impact Factor has been Increased to 7.065 for Year 2024.

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia