FORMULATION AND EVALUATION OF ONCE-A-DAILY OXYBUTYNIN CHLORIDE EXTENDED RELEASE MATRIX TABLET FOR OVER ACTIVE BLADDER SYNDROME

Bhargavi Vaidya, Anand Kumar Y.* and Srikanth

ABSTRACT

The aim of present research work is to prepare and evaluate oxybutynin chloride once a daily extended release matrix tablets by wet granulation method using rate controlling polymers viz., ethyl cellulose, eudragit RL 100 and guar gum at three proportions viz., 25%, 40% and 60% w/w. The tablets were evaluated for precompression and postcompression parameters. FTIR studies indicate the polymers are compatible with drug, the precompression values were within the acceptable limit and suitable for compression, drug content and weight variation were acceptable as per the IP specification. The hardness and friability results indicate the tablets possess good mechanical strength. The in vitro drug release was extended up to 24h, except tablets prepared with guar gum the total drug was released within 18h. Overall results suggest among the polymers rate retarding was dependent on type, nature of the polymer and concentration. The more retarding drug release was observed in batch containing 60% w/w polymer when compared to 40% w/w and 25% w/w polymer after 24h. The peppas exponential n > 0.5 values indicate the mechanism of drug release followed non ficknian and is controlled by erosion followed by diffusion.

Keywords: Oxybutynin chloride, Ethyl cellulose, Guar gum, Eudragit RL 100, In vitro dissolution.