SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL PROPERTY OF NOVEL TRIAZOLE DERIVATIVES AS UNUSUAL AMINO ACID
Hricha Joshi*, Ajay Singh Bisht and Divya Juyal
Excellent and broad bio-spectrum of triazole has lead to an attractive scope for the synthetic chemists for the introduction of structural modification in the nucleus so as to make access to new approaches and opportunities. A new technique for the incorporation of amino acids in the heterocyclic nucleus has been developed and hence the term to the resultant compounds can be given as unusual amino acid because of having the groups similar to amino acids but being nonpeptidogenic in nature. The name of the final compounds as unusual amino acids are 4- (acetic acid)-3(3-pyridyl)-5-thione-1,2,4-triazole, 4-(propionic acid)-3(3-pyridyl)-5-thione-1,2,4- triazole and 4-(butanoic acid)-3(3-pyridyl)-5-thione-1,2,4-triazole. The reaction and purity of the compounds is checked by TLC and melting point. The characterization of the compounds is performed by 1D-NMR and IR. The antibacterial activity is done on two strains of bacteria gram negative and gram positive.
Keywords: Triazole, unusual amino acids, nonpeptidogenic, antibacterial, NMR, IR.
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