ACUTE AND CHRONIC ANTI-INFLAMMATORY EFFECT OF ETHANOL EXTRACT OF THE RESIN EXUDATES OF BOSWELLIA DALZIELII HUTCH (BURCERACEAE) IN MICE
Jeweldai Vedekoi*, Selestin Dongmo Sokeng, Pierre Kamtchouing, Juliette Koubé, Jeanne Assiga Ahanda, Tchinmie Elisabeth
Boswellia dalzielii (Burseraceae) has been used in folkloric medicine to treat diseases related to inflammation. The present work was aimed to access the acute and chronic anti-inflammatory effects of the ethanol extract of the resin of B. dalzielii (EERBD) in mice. The anti-inflammatory effect was evaluated in three experimental models: Doses of 100, 200 and 400 mg/kg of EERBD were administered orally in carrageenan-induced rat hind paw oedema, xylene-induced ear oedema in mice, and cotton pellet-induced granuloma formation), using dexamethasone 1 mg/kg as standard drugs in mice. Phytochemical analysis indicated that the EERBD contains pharmacological compound, namely: polyphenol, tannins, reducting sugars, alkaloids, saponins, sterols, and triterpènes. Results obtained showed that The EERBD possessed a significant (p < 0.001) anti-inflammatory activity which compared with the negatif control at the first hour with 83.39%, 74.19%, 85.74% and 88.99% respectively, as a percentage inhibition for the 100, 200 and 400 mg /kg. On the other hand, in the xylene induced edema test, the extract at the same doses, also exhibited an anti-inflammatory activity. The ethanol extract of resins of B. dalzielii Hutch, in a 7-day study, daily administration of B. dalzielii suppressed cotton pallet-induced rat granuloma formation. These results might be suggested that B. dalzielii can be used as anti-inflammatory medicine.
Keywords: B. dalzielii, Anti-inflammatory, carrageenan-induced, paw edema, xylene-induced edema, cotton pellets granuloma.
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