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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

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European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57



Wajiha Gul*, Fouzia Hamid, Sidra Ayub, Sania Bhatti


Fluoroquninolones are a family of broad-spectrum synthetic antimicrobial agents having particular activity against gram-negative organisms especially Pseudomona aeroginosa. These compounds have a fluoro group attached to the central ring system. Nalidixic acid is the parent compound of the group introduced in 1962. They are classified as 1st, 2nd, 3rd and 4th generation fluoroquinolones having nalidixic acid, ciprofloxacin, levofloxacin and moxifloxacin belonging to the classes respectively. These are bactericidals and acts by attacking the DNA gyrase and topoisomerase in gram-negative and –positive bacteria respectively.[1,3] The activity may reduce in acidic media.[4] These are well-absorbed orally and cannot cross BBB, have major adverse effects GIT related however CNS related ADR are severe but rare.[3,5,6] Heterocyclic quinolones stand for diverse biological and chemical reactivity.[7] The Quinolonecarboxylic acids, carboxyquuinoloes, or 4- quinolones are a group of synthetic antibacterials structurally related to nalidixic acid. The term 4- quinolone has been used as a generic name for the common 4-oxo-1, 4- dihydroquinoline skeleton. Under this system nalidxic acid, a napthyridene derivative, is an 8- aza-4 quinolone, cinoxacin, a cinnoline derivative, is a 2-aza-4-quinolone, and pipemidic and piromidic acids, pyridopyrimidine derivatives, 6,8-diaza-4-quinolones.[8]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia