DEGRADATION STUDIES OF SELECTED FLUOROQUINOLONES
Wajiha Gul*, Fouzia Hamid, Sidra Ayub, Sania Bhatti
Fluoroquninolones are a family of broad-spectrum synthetic antimicrobial agents having particular activity against gram-negative organisms especially Pseudomona aeroginosa. These compounds have a fluoro group attached to the central ring system. Nalidixic acid is the parent compound of the group introduced in 1962. They are classified as 1st, 2nd, 3rd and 4th generation fluoroquinolones having nalidixic acid, ciprofloxacin, levofloxacin and moxifloxacin belonging to the classes respectively. These are bactericidals and acts by attacking the DNA gyrase and topoisomerase in gram-negative and –positive bacteria respectively.[1,3] The activity may reduce in acidic media. These are well-absorbed orally and cannot cross BBB, have major adverse effects GIT related however CNS related ADR are severe but rare.[3,5,6] Heterocyclic quinolones stand for diverse biological and chemical reactivity. The Quinolonecarboxylic acids, carboxyquuinoloes, or 4- quinolones are a group of synthetic antibacterials structurally related to nalidixic acid. The term 4- quinolone has been used as a generic name for the common 4-oxo-1, 4- dihydroquinoline skeleton. Under this system nalidxic acid, a napthyridene derivative, is an 8- aza-4 quinolone, cinoxacin, a cinnoline derivative, is a 2-aza-4-quinolone, and pipemidic and piromidic acids, pyridopyrimidine derivatives, 6,8-diaza-4-quinolones.
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