INVESTIGATION OF HUMORAL IMMUNITY, PHAGOCYTOSIS INDEX & SOME OF HEMATOLOGICAL PARAMETERS IN PATIENTS OF RHEUMATOID ARTHRITIS IN THI-QAR PROVINCE

*Ali Naeem. Salman and Ahlam. Muhsen.Kudair

ABSTRACT

The current study was conducted at the laboratories of Biology Dept, Collage of education for pure science–Thi-Qar Univ, during the period from October 2014 to May 2015. The study aimed to evaluate immune status of Rheumatoid arthritis (RA) patients by measuring the levels of immunoglobulin's (IgM, IgG) by single redial immune diffusion (SRID) and the study included test phagocytic cells on phagocytosis (coefficient of phagocytosis) and measurement hematological parameters (hemoglobin, packed cell volume and count the total and differential white blood cells). The study included a total of 100 patients with RA (25 males) and (75 females) and there aged between (20-65) years. Levels were measured in serum immunoglobulins for 20 samples of patients with RA, also examined the levels of immunoglobulins in the serum of 10 samples from healthy people in the control group. The results of the statistical analysis showed high significant increase (P ≤ 0.001) in the immunoglobulins in serum IgM, IgG in patients with RA compared with healthy control group. inecrease coefficient phagocytosis was significantly (P ≤ 0.001) in all patients with RA compared to the group of control, either with respect to the hematological parameters have explained the results of the current study, the lack of significant differences( P ≤ 0.05) in the rates of the values of Hb and PCV in all patients RA, compared with the control group, also increased the rate of counting the total of WBCs and count differential cells neutrophils, monocyte, lymphocytes and platelets (P ≤ 0.001) in patients with RA compared with healthy people in the control group.

Keywords: RA, IgG, IgM, Phagocytosis, lymphocytes, WBCs count, PCV.