EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

THE IMPORTANCE OF HEREDITY IN THE DEVELOPMENT OF UTERINE FIBROIDS

Isanbaeva L. M.*

ABSTRACT

Background: The problem of early diagnostics of myomas utera is rather actual and necessary. In the structure of gynecological diseases myoma utera is 35-65%. Significant role in susceptibility to tumors have histocompatibility system antigens - HLA. Objective: to study the histocompatibility antigens of the HLA-I class in the native women of Tashkent with the hysteromyoma. Methods: An immunogenetic analysis was made up to the antigens of HLA-I class in 177 native women of Tashkent with hysteromyoma. To define the serologic typing of the antigens of HLA-I class the purified lymphocytes suspension that was isolated by the method of A. Boyum (1968). HLA-phenotype was established at the microlymphocytotoxicity assay of P. Terasaki (Mittal K., Terasaki P., et al. 1968) [7] using the HLA-antiserum panel of the SRI of Hematology and the hemotransfusion, ―Gisans‖ firm in St. Petersburg.Results: A positive association at the risk of the hysteromyoma development with HLA-B8, B22 and A28 antigens was stated. The Cw5 antigen played the role of the addition markers. The HLA-A2, B35, Cw4 antigens were determined with a negative association. Conclusion: The immunogenotypic analysis revealed HLA-antigens of the HLA-I class, that are typical for the hysteromyoma in the native women of Tashkent. The results of analyses allows to determine the individuals with a high risk of the hysteromyoma development and to diagnose the disease at an early stage and the providing of the range of preventive measures directed to prevent the hysteromyoma development.

Keywords: hysteromyoma, tumors, HLA-system antigens and haplotypes.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )