EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

HEPATOTOXIC EFFECT OF TARTRAZINE AND ERYTHROSINE ON MALE WISTAR RATS

Wopara Iheanyichukwu*, Mounmbegna P. P. E., Ike Amanda and Modo Emmanuel U.

ABSTRACT

Recently, progressive use of synthetic food additives has paid more attention on their benefit and less attention on their toxic effect. Tartrazine and erythrosine are synthetic food colorants widely used in food, cosmetics and pharmaceuticals industries. This study is aimed at evaluating the possible hepatotoxic effect of these synthetic food colorants. A total of 25 adult male albino rats were divided into five groups with 5 rats per group. Group 1 is control group and given only water and feed. While group 2,3,4,5 were administered 5mg/kgb.wt, 10mg/kgb.wt, 20mg/kgb.wt, 40mg/kgb.wt of Tatrazine and Erythrosine respectively. At the end of the experimental period (21 days), blood samples were collected via ocular puncture and used to measure the serum activity of Alanine aminotranferase (ALT), Aspartate aminotranferase (AST) and Alkaline phosphatase (ALP), on the animals. The result revealed that there was a high significant difference p<0.05 in ALT activity of group4 (8.98±2.49U/L) when compared with the control (3.21±0.09U/L). Group5 also showed higher ALT activity (7.66±0.37U/L) when compared with group2 (1.98±0.18U/L). Also, AST activity in group5 was significantly higher (68.53±2.23U/L) when compared with the control (3.11±0.18U/L).the increase was observed across group. Furthermore, the result showed a high serum ALP activity in group4 (26.01±2.04U/L) when compared with the control (16.00±1.09U/L) and other groups. The above result shows that the combination of Erythrosine and Tartrazine is capable of increasing the serum activity level of the liver enzymes (ALT,AST and ALP). This implies that high and constant ingestion of these synthetic food colorants could be hepatotoxic, hence liver damage.

Keywords: Erythrosine, Tartrazaine, AST, ALT and ALP.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )