EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

LINAGLIPTIN AMELIORATES HEPATIC DERANGEMENT AND ENDOTHELIAL DYSFUNCTION IN TYPE 2 DIABETIC RATS: BIOCHEMICAL, FUNCTIONAL AND HISTO-MORPHOMETRIC ANALYSIS

Hazem F. Mannaa*, Tarek A. Abd Allah, Wafaa A. Hewedy, Eiman I. Zaki, Salma H. Kandiel

ABSTRACT

Introduction: Management of diabetes mellitus and its complications remains a worldwide health challenge. Type 2 diabetes mellitus (T2DM) is linked to wide arrays of macrovascular and microvascular complications; where endothelial dysfunction plays the primary step in their development. T2DM is also accompanied by variable liver-related complications; regardless of the glycemic control. The formation of advanced glycation end-products (AGEs) is recognized as a key factor in the development of many diabetic complications. Aim: The current study was designed to evaluate the possible hepatoprotective and vascular protective effects of linagliptin in a rat model of T2DM. Material and methods: DM was induced by a combination of high-fat diet administration and a single intraperitoneal injection of streptozotocin. Serum metabolic indices, liver lipid contents, liver function tests and serum advanced glycation end products (AGEs) were determined. Sections of the liver were used for histological and morphometric analysis. The response of aortic ring preparations to different doses of norepinephrine and acetylcholine, in vitro, was also evaluated. Results: Linagliptin significantly attenuated fasting blood glucose, plasma insulin, insulin resistance, serum lipids and hepatic contents of cholesterol and triglyceride compared to the diabetic rats. It also reverted the liver near normal structure. Moreover, linagliptin treatment improved the impaired relaxations of aortic rings of diabetic animals. Conclusion: Linagliptin treatment can ameliorate hepatic derangement, endothelial dysfunction in this animal model of type 2 diabetes.

Keywords: Advanced glycation end products; endothelial dysfunction; fatty liver; linagliptin.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )