EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

FETUIN-A, INDOXYLY SULFATE, VITAMIN K ANTAGONISTS EFFECTS ON VASCULAR CALCIFICATION AND AVF: A SYSTEMATIC REVIEW

Mercy Julian Mwamunyi, Zifang Li and Li-Jun Yao*

ABSTRACT

Background: Vascular calcification (VC) is a surrogate marker of vascular health. Functional vitamin K antagonists (VKA), fetuin-a and indoxyl sulfate (IS), are reported to have impacts on vascular calcification and may have clinical potential to modify the progression of vascular calcification and arteriovenous fistula failure status in the end stage renal disease. Methods: Studies evaluating the relationship of VKA, Fetuin-A, and IS with VC by at least stating one of the circulating compounds in animal models or patients either with CKD or patients receiving regular hemodialysis or on AVF were systematically identified. We searched English literature from January 1990 to November 2018 on the online MEDLINE and EMBASE. Results: Eight studies comprising a combined population of 2,766 participants were included after screening 449 distinctive abstracts. The included studies examined VKA, fetuin-a, IS effect on VC, and AVF. Conclusion: This paper is the first systematic review of the effect of vitamin K antagonists, Fetuin-A and IS status in VC and AVF. Our results suggest the quantification of the non-functional fractions of fetuin-a, IS, and VKA advocates their potential for detecting specific vascular calcification development in several patient cohorts. Lower fetuin-a levels and VKA in CKD subjects was linked to AVF failure. Further, studies with larger sample sizes are needed to enlighten whether their assessment can be of any clinical significance.

Keywords: fetuin-a, indoxyl sulfate, vitamin K antagonists, AVF, vascular calcification.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )