EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

PREPARATION, OPTIMIZATION AND EVALUATION OF CELECOXIB PRONIOSOMAL GEL

Sangeeta Bohra, Srikanth* and Anand Kumar Y.

ABSTRACT

In the present work an attempt was made to formulate and evaluate celecoxib proniosomal gels. The proniosomal gels were prepared by coacervation phase separation method using nonionic surfactants (span 60, span 40): cholesterol, lecithin and drug then it was incorporated into 0.75% of carbopol gel. Further formulations were evaluated for entrapment efficiency, drug content, size and shape, in vitro drug release and skin irritation studies. The particle size distribution of all formulations were in the range 4.43-4.91μ. Zeta potential value and zeta potential analysis were-78.3Mv and 1442 d.nm for (SF3) formulation. The skin irritation potential was 0.31 suggesting the (SF3) formulation was nonirritant to the rabbit skin. The highest entrapment efficiency was found in formulation (SF3) 96.01 ± 0.45% and cumulative percent drug release was observed with 86.19±0.15 over the period of 24h. In vitro kinetic model fitting suggest that the best fit model was hixon crowel with korsemayer peppas exponential „n‟ value <0.5 indicating that drug was released by non fickian mechanism. These results indicate that proniosomal gels have a promising carrier for the transdermal delivery of celecoxib. Thus celecoxib can be formulated into a low dose proniosomal gel that can save the recipient from the adverse effects of large doses.

Keywords: Proniosomal gel, Celecoxib, Cholesterol, Span 60, Span 40, Lecithin.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia