EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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 ICV - 79.57

Abstract

A HIGHLY SENSITIVE AND SELECTIVE SPECTROFLUORIMETRIC METHOD FOR THE DETERMINATION OF LITHIUM AT PICO-TRACE LEVELS IN SOME REAL, PHARMACEUTICAL FORMULATIONS, BIOLOGICAL FLUIDS, SOIL AND FOOD SAMPLES USING 5,7-DIBROMO-8-HYDROXYQUINOLINE

Ayesha Afrin, Tanjina Akhter and M. Jamaluddin Ahmed*

ABSTRACT

A very simple, rapid, ultra-sensitive, highly selective and non-extractive spectrofluorimetric method for the determination of lithium at pico-trace levels using 5,7-dibromo-8-hydroxyquinoline(DBHQ) has been developed. DBHQ reacts in a slightly acidic (0.0003-0.0015 M H2SO4) aqueous solution with lithium in 30% ethanolic media and to form intensely fluorescent chelate, which has high fluorescence intensity (ex =278 nm; em=342 nm). The reaction is instantaneous and the fluorescent intensely remain stable for the period between 1 min and 24 h. Linear calibration graphs were obtained for 0.001- 400-μg L-1 of Li, with a R2 = 0.99987, having a detection limit of 0.1-ng L-1; the quantification limit of the reaction system was found to be 1-ngL-1 and the RSD was 0-3%. The stoichiometric composition of the chelate is 1:1 (Li:DBHQ). A large excess of over 60 cations, anions and complexing agents (like, chloride, phosphate, azide, tartrate, oxalate, SCN- etc.) do not interfere in the determination. The developed method was successfully used in the determination of lithium in several Certified Reference Materials (alloys, steels, sediments, human hair, bovine liver, fresh water, and rice flour) as well as in some lithium in commercial pharmaceutical formulations (tablet, syrup, drop and capsule) and biological fluids (human blood, urine and milk), soil, food samples. The results of the proposed method for assessing biological, food and pharmaceutical samples were comparable with ICP-OES and were found to be in excellent agreement. The results of the proposed method for assessing pharmaceutical samples were also comparable with the Official method stated in the U. S. Pharmacopoeia and were found to be in an excellent agreement. The method has high precision and accuracy (s ±0.01for 0.5μgL-1).

Keywords: Spectrofluorimetry; lithium determination; pharmaceutical formulations; biological fluids; food and vegetables samples.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )