EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

CLINICAL EVALUATION OF MANJISTHADI GHAN VATI IN DIABETIC NEUROPATHY – AN OPEN LABELED, NON COMPARATIVE CLINICAL STUDY

Dr. Narendra Mundhe*, Dr. Kuldip Raj Kohli and Dr. Sanjay Tamoli

ABSTRACT

Diabetic Neuropathy (DN) is a common complication of Diabetes Mellitus (DM). Continuous efforts are ongoing to find a satisfactory treatment for this condition. Various Ayurvedic herbs and formulations have been reported to be useful in Diabetes and its complications including DN. In the present study an Ayurvedic formulation - Manjisthadi Ghan Vati (MGV) was evaluated for its effect on patients of Peripheral Diabetic Neuropathy. MGV was given in a dose of 2 tablets of 500 mg twice daily for 90 days. Monthly evaluation of subjects was done for various clinical signs and symptoms of DN. Nerve conduction velocity (NCV) was done at the beginning and end of the study. Significant improvement was observed in almost all the symptoms of Peripheral Diabetic Neuropathy like burning sensation of the hands and feet, tingling sensation, numbness of the extremities, hyperesthesia, hypoesthesia, weakness and cramps. Of the 30 subjects evaluated for NCV, 15 subjects (50%) showed significant improvement in their nerve conduction while 13 subjects (43.33%) showed no change and 2 subjects (6.66%) showed slight worsening in their nerve conduction. The study drug was found to be safe with no significant changes in the safety laboratory parameters like Liver function tests, Renal Function tests, Lipid profile and Complete Blood count over 90 days. The study provides good evidence in support of efficacy and safety of MGV in Diabetic Neuropathy.

Keywords: Manjisthadi Ghan Vati, Peripheral Diabetic Neuropathy, Nerve Conduction Velocity.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )