EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

IMPACT OF ETHANOLIC EXTRACT OF SENNA AURICULATA, PHYLLANTHUS EMBLICA.L., SYZYGIUM CUMINI(L.) SKEELS USED BY RURAL AREAS OF RAJASTHAN STATE, INDIA ON DIABETIC NEUROPATHY IN RATS.

Ashish Kumar Sharma* and Charanjeet Singh

ABSTRACT

Purpose of the research: India is ―diabetes capital of the world‖. Rise to 69.9 million by 2025; major causes of morbidity and mortality. Herbal formulations are preferred to minimize the risk and low cost, traditionally. Metohods: Alloxan(150mg/kg)i.p. results in diabetic rats given Senna auriculata leaf, Phyllanthus emblica.L. fruits and Syzygium cumini(L.) Skeels seeds(150 mg/kg)p.o. extracts, for 42 days. Parameters of diabetic neuropathy and histopathology was done. The Principal Results: In Diabetics, Blood Glucose level(BGL)(84.42±6.384 to 369.36±7.784mg/dl); Muscle Grip Strength(MGS)(59.32±1.052 to 13.52±0.883seconds); thermal pain response(TPR) (5.55±0.621 to 13.67±1.164seconds). blood protein(7.48±0.051 to 25.18±0.046mg/dl); urine protein(0.692±0.061 to 2.68±0.056mg/dl); blood albumin(1.94±0.043 to 0.248±0.007mg/dl); urine albumin(0.082±0.009 to 2.68±0.056mg/dl);. Ethanolic extract of Senna auriculata leaf, Phyllanthus emblica.L. fruits and Syzygium cumini(L.)Skeels seeds & combination treated groups found BGL124.42±7.042, 112.07±6.942, 126.25±7.051 & 98.83±6.932mg/dl; MGS49.06±0.962, 52.05±1.247, 54.06±1.268 &56.79±1.125seconds; TPR6.54±0.841, 7.38±0.802, 6.45±1.062 & 6.14±0.837seconds; blood protein7.98±0.039, 8.02±0.053, 8.06±0.039 & 7.48±0.045mg/dl; urine protein1.22±0.058, 0.94±0.049, 0.96±0.056 & 0.82±0.062mg/dl; blood albumin1.64±0.033, 1.82±0.036, 1.87±0.044 & 1.96±0.039mg/dl; urine albumin0.122±0.008, 0.098±0.007, 0.132±0.009 & 0.108±0.011mg/dl. Conclusions: Combination of Senna auriculata leaf, Phyllanthus emblica.L. fruits and Syzygium cumini(L.) Skeels seeds (150 mg/kg) p.o. extracts normalizes biochemical parameters & Morphological changes sciatic nerve and improves behavioral parameters, effective in treatment of diabetic neuropathy.

Keywords: Senna auriculata leaf; Phyllanthus emblica.L. fruits; Syzygium cumini(L.)Skeels seeds; diabetic neuropathy.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )