EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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 ICV - 79.57

Abstract

IMMUNOMODULATORY AND ANTIOXIDANT ACTIVITY OF HYDRO-ALCOHOLIC EXTRACT OF CAESALPINIA PULCHERRIMA (AERIAL PARTS)

*Kumar Ashish, Chakraborthy G. S., Gupta Sushma, Das Saumya, Kumar Manish and Chauhan Nidhi

ABSTRACT

Aim of the study: In the present study the immunomodulatory and the antioxidant activity of aerial parts of Caesalpinia pulcherrima were investigated by in vitro and in vivo methods. Materials and methods: The hydro-Alcoholic extract was screened for various phytoconstituents and tried for co-relation with biological activity. Hydro-alcoholic extract was tested for antioxidant by DPPH radicals scavenging activity and hydrogen peroxide scavenging (H2O2) assay. Immunomodulatory activity was evaluated by delayed-type hypersensitivity (DTH) response and percentage adhesion of neutrophils to nylon fibers compare with control group. Results: The evaluation of immunomodulatory potential of Caesalpinia pulcherrima (100, 250 and 500 mg/kg, p.o.) evoked a significant dose-dependent increase in DTH reaction induced by SRBC and at higher dose significantly (P<0.01) increased the percentage of adhesion of Neutrophils to nylon fibers when compared with the normal animals group. The results were comparable with control group. Hydro-alcoholic extract of Caesalpinia pulcherrima showed significant immunomodulatory and antioxidant activity. The hydro alcoholic extract showed significantly the highest % of inhibition of DPPH scavenging ability and H2O2 assay when compare to chloroform and ethanolic extract but minute less to ascorbic acid as a reference. Conclusion: The present investigation supports the use of Caesalpinia pulcherrima for their immunomodulatory and antioxidant effects. Hydro-Alcoholic extract of Caesalpinia pulcherrima contains bioactive principles, which possess immunostimulant activity.

Keywords: Caesalpinia pulcherrima, Immunomodulatory, Antioxidant, DTH Activity, Neutrophil adhesion test, Hydro-Alcoholic extract.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia