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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Ajanthan R.* and Manoharan A.


Background: The Plant is the important source of bioactive compound. The Kadukkai chooranam (Terminalia chebula Retzius) has been mentioned in various classical siddha literatures. The text book Gunapadam Mooligai Vaguppu (Murugesu Mudaliyar C.S, 2013), and Kadukkai, Vallari in thani manbu(Hakeem P.Mohamatu Abthulla Shajabu. 1992) clearly mentioned in therapeutic effects of Akkini selathumam and it has been similarly correlated symptoms in modern medicine is Diabetic neuropathy. Objective: To determined and found the acute and sub-acute toxicity of kadukkai chooranam (KC) on Wister Albino rat. of Kadukkai chooranam (KC) was carried out as per the (OECD)-423 guidelines after getting the confirmation about the animal ethical clearance Committee. In the acute toxicity study were carried out female albino Wister rats, after single oral dose (50 mg/kg) administration of Kadukkai chooranam(Kc), in sub acute toxicity study male and female albino rats were administered daily oral doses (50, 100,200 and 400 mg/kg respectively) of Kadukkai chooranam(KC) for 28 days. At the end of the study, the animals were humanely sacrificed and assessed for the effect of Kadukkai chooranam(KC), assessed by body weight, haematological, biochemical and histopathological investigations. Results: In the acute toxicity study no mortality or behavioral changes were observed after using in single dose of Kadukkai chooranam(KC) (2000 mg/kg). indicating that the LD50. Conclusion: These results exhibit the absence of acute and sub acute oral toxicity after treatment of Kadukkai chooranam (KC) in rats. However, further clinical studies humans are needed in order to have sufficient safety evidence for its use in humans.

Keywords: Kadukkai chooranam, Siddha Medicine, Toxicity studies, Albino rats.

[Full Text Article]



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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )