ACUTE AND SUB ACUTE TOXICITY STUDY OF SIDDHA DRUG KADUKKAI CHOORANAM (TERMINALIA CHEBULA, RETZIUS)

Ajanthan R.* and Manoharan A.

ABSTRACT

Background: The Plant is the important source of bioactive compound. The Kadukkai chooranam (Terminalia chebula Retzius) has been mentioned in various classical siddha literatures. The text book Gunapadam Mooligai Vaguppu (Murugesu Mudaliyar C.S, 2013), and Kadukkai, Vallari in thani manbu(Hakeem P.Mohamatu Abthulla Shajabu. 1992) clearly mentioned in therapeutic effects of Akkini selathumam and it has been similarly correlated symptoms in modern medicine is Diabetic neuropathy. Objective: To determined and found the acute and sub-acute toxicity of kadukkai chooranam (KC) on Wister Albino rat. of Kadukkai chooranam (KC) was carried out as per the (OECD)-423 guidelines after getting the confirmation about the animal ethical clearance Committee. In the acute toxicity study were carried out female albino Wister rats, after single oral dose (50 mg/kg) administration of Kadukkai chooranam(Kc), in sub acute toxicity study male and female albino rats were administered daily oral doses (50, 100,200 and 400 mg/kg respectively) of Kadukkai chooranam(KC) for 28 days. At the end of the study, the animals were humanely sacrificed and assessed for the effect of Kadukkai chooranam(KC), assessed by body weight, haematological, biochemical and histopathological investigations. Results: In the acute toxicity study no mortality or behavioral changes were observed after using in single dose of Kadukkai chooranam(KC) (2000 mg/kg). indicating that the LD50. Conclusion: These results exhibit the absence of acute and sub acute oral toxicity after treatment of Kadukkai chooranam (KC) in rats. However, further clinical studies humans are needed in order to have sufficient safety evidence for its use in humans.

Keywords: Kadukkai chooranam, Siddha Medicine, Toxicity studies, Albino rats.