EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

FORMULATION AND EVALUATION OF MATRIX TABLET OF DILTIAZEM HYDROCHLORIDE FOR CONTROLLED RELEASE

Rashmitha N. M.*, C. N. Somashekhar, Shravya Lakshmi S. and T. Tamizh Mani

ABSTRACT

The present study is the development of controlled release matrix tablets of anti-hypertensive drug Diltiazem hydrochloride by direct compression method. Hydroxy propyl methyl cellulose (HPMC) LV15 and LV5 are used as rate retarding polymer. The effect of the different concentration of the polymer and the influence of different grade of HPMC on the release rate of drug was investigated. Diltiazem hydrochloride release from HPMC LV15 and HPMC LV5 matrices are mainly controlled by the drug – polymer ratio. The prepared matrix tablets were evaluated for post-compression parameters such as hardness, friability, thickness, % weight variation, % drug content and in-vitro dissolution test. From the in-vitro study F3 formulation showed better controlled release till 12 hrs, this is due to high viscosity grade with high ration of HPMC.

Keywords: Diltiazem hydrochloride, controlled release, Hydroxy propyl methyl cellulose, Dissolution.

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