ANTI HYPERLIPIDEMIC ACTIVITY OF SIDDHA DRUG KARIVEPPILAI CHOORANAM IN HYPERLIPIDEMIC INDUCED WISTAR ALBINO RAT MODELS

Manoharan A.* and Chittibabu C. V.

ABSTRACT

Hyperlipidemia is a major risk factor in Cardio Vascular and Central nervous systems. Hyperchloestredemia is a most important condition involving in abnormal levels of lipids (or) composition of circulatory plasma levels. Recent studies have been reported that hyperlipidemia is present in 25-30% of urban and 15-20% rural area subjects (Rajveev Gupta et al. 2017). In India few larger studies have reported of different form of lipid abnormalities (ICMR INDIA B STUDY 2011, 2014 and PURE study (Camacho PA 2019). Aim: The present study was carried out to determine the anti hyperlipidemic activity of Kariveppilaichoornam. Material and Methods: Anti hyperlipidemic activity assay was performed by high fat diet induced Wister albino rat models, atrovastitin was used as the reference standard respectively. Stastical Analysis Used: All the experiments were performed the values are expressed as Mean ± SEM. Values were find out by using ONE WAY ANOVA followed by Newman Keul’s multiple range tests. Values were significantly different from normal control at P< 0.01. Values were significantly different from hyperlidemic control at P< 0.01. P values <0.05 were considered as statistically significant. Results: End of study shows KVC 100 to 200 mg dosage was reduced in lipid level, especialy in total cholesterol and triglycerides. Conclusion: The KVC has significant hypolipidemic effects on HFD diet induced Wister albino rats.

Keywords: Hyperlipidemia, Dyslipidemia, Obesity, Kariveppillai Choornam.