A STUDY OF AQUEOUS LEAF EXTRACT OF BRASSICA OLERACEA (RED CABBAGE) AGAINST EXPERIMENTALLY INDUCED ALZHEIMER’S DISEASE IN MICE

Pallavi*, Satish S. and A. R. Shabaraya

ABSTRACT

Objective: A study on aqueous leaf extract of brassica olaracea (ALEB) against experimentally induced Alzheimer’s disease in mi e. Methods: Cognitive enhancing activity of ALEB on scopolamine induced memory impairment in mice was investigated by using behavioral parameters viz, Morris water maze, Passive shock avoidance paradigm and estimation of biochemical parameter was carried in terms of AChE activity. Two doses (500mg/kg) and (1000mg /kg b.wp.o) of ALEB were subjected for the study against experimentally induced Alzheimer’s disease by scopolamine (0.4mg/kg, i.p) in young mice. Piracetam (400 mg/kg i.p) was served as standard in both the models. Results: The long term administration of both the lower (500mg/kg) and higher dose (1000mg/kg) of ALEB produced significant reduction of ELT in MWM, And increase of TSTQ and SDL value in MWM and PSAP model on both 19th and 27th day when compared with control and induced groups. ALEB at higher dose significantly reduce the activity of AchE in the brain indicates the improvement in learning and retention of memory in young mice. Conclusion: The present study concluded that ALEB was found to be effective against amnesia induced by scopolamine.

Keywords: Nootropic, Scopolamine, ALEB, PSAP, MWM, Young mice.