EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

A STUDY OF AQUEOUS LEAF EXTRACT OF BRASSICA OLERACEA (RED CABBAGE) AGAINST EXPERIMENTALLY INDUCED ALZHEIMER’S DISEASE IN MICE

Pallavi*, Satish S. and A. R. Shabaraya

ABSTRACT

Objective: A study on aqueous leaf extract of brassica olaracea (ALEB) against experimentally induced Alzheimer’s disease in mi e. Methods: Cognitive enhancing activity of ALEB on scopolamine induced memory impairment in mice was investigated by using behavioral parameters viz, Morris water maze, Passive shock avoidance paradigm and estimation of biochemical parameter was carried in terms of AChE activity. Two doses (500mg/kg) and (1000mg /kg b.wp.o) of ALEB were subjected for the study against experimentally induced Alzheimer’s disease by scopolamine (0.4mg/kg, i.p) in young mice. Piracetam (400 mg/kg i.p) was served as standard in both the models. Results: The long term administration of both the lower (500mg/kg) and higher dose (1000mg/kg) of ALEB produced significant reduction of ELT in MWM, And increase of TSTQ and SDL value in MWM and PSAP model on both 19th and 27th day when compared with control and induced groups. ALEB at higher dose significantly reduce the activity of AchE in the brain indicates the improvement in learning and retention of memory in young mice. Conclusion: The present study concluded that ALEB was found to be effective against amnesia induced by scopolamine.

Keywords: Nootropic, Scopolamine, ALEB, PSAP, MWM, Young mice.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )