FORMULATION AND IN-VITRO CHARACTERISATION OF METRONIDAZOLE LOADED GASTRORETENTIVE BEADS FOR H. PYLORI INFECTION MANAGEMENT

Snehal Y. Kane* and Munira Momin

ABSTRACT

Aim of the research work is to formulate metronidazole loaded gastroretentive dosage form for the better eradication in the management of H. Pylori infection. In the present study multiparticulate dosage form was prepared by gelling and cross liking method using sodium alginate and calcium chloride. Further carbopol 934 P and HPMC 4M were used as release retardants and calcium carbonate was used as effervescent substance. Formulations were evaluated for particle size, % yield, % drug loading, % efficiency, mucoadhesion, floating lag time and swelling index. All formulation were subjected for dissolution study for 12hr. Batch F1 with only sod. Alginate did not float and showed very slow drug release. Batch F2 to F4 showed good mucoadhesion due to presence of Carbopol 934 p. Batch F6 with HPMC K4M as release retardant showed mucoadhesion and floating when used with calcium carbonate. F9 batch with sodium alginate and HPMCK4 M as 1:1 proportion and 0.25 gm of calcium carbonate showed floating lag time of 1 min with 62.02%mucoadhesion and 96.15%drug release in 10 hr was considered as most acceptable batch.

Keywords: Gastroretentive Beads, Metronidazole, Helicobacter Pylori, Floating Beads, Multiparticulate System.