EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

FORMULATION AND IN-VITRO CHARACTERISATION OF METRONIDAZOLE LOADED GASTRORETENTIVE BEADS FOR H. PYLORI INFECTION MANAGEMENT

Snehal Y. Kane* and Munira Momin

ABSTRACT

Aim of the research work is to formulate metronidazole loaded gastroretentive dosage form for the better eradication in the management of H. Pylori infection. In the present study multiparticulate dosage form was prepared by gelling and cross liking method using sodium alginate and calcium chloride. Further carbopol 934 P and HPMC 4M were used as release retardants and calcium carbonate was used as effervescent substance. Formulations were evaluated for particle size, % yield, % drug loading, % efficiency, mucoadhesion, floating lag time and swelling index. All formulation were subjected for dissolution study for 12hr. Batch F1 with only sod. Alginate did not float and showed very slow drug release. Batch F2 to F4 showed good mucoadhesion due to presence of Carbopol 934 p. Batch F6 with HPMC K4M as release retardant showed mucoadhesion and floating when used with calcium carbonate. F9 batch with sodium alginate and HPMCK4 M as 1:1 proportion and 0.25 gm of calcium carbonate showed floating lag time of 1 min with 62.02%mucoadhesion and 96.15%drug release in 10 hr was considered as most acceptable batch.

Keywords: Gastroretentive Beads, Metronidazole, Helicobacter Pylori, Floating Beads, Multiparticulate System.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )