EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

PRAGMATIC ASSESSMENT OF THREE CAUSALITY ASSESSMENT SCALES FOR REPORTING ADVERSE DRUG REACTIONS: A PROSPECTIVE AND RETROSPECTIVE ANALYSIS

Ms. Kalpana Purohit, Dr. Bhomik Goel, Dr. Yusra Ahmed, Dr. Ravi Kant and Dr. Puneet Dhamija*

ABSTRACT

Objective: Causality assessment is an integral part of reporting of adverse drug reactions. This assessment is done at all the steps of evaluation of adverse effects. The time and resources available for causality assessment are different at different levels which affects the process. Additionally, there is no universally accepted measure for causality assessment presently. Methods: Three scales of causality assessment of Adverse Drug Reaction (ADR) namely WHO, Naranjo and Karch & Lasagna scales were compared for agreement of causality categories and time consumed to assign categories to 500 ADR detected retrospectively and prospectively. Results: The findings of present study demonstrated a good agreement between WHO and Karch and Lasagna scale (k = 0.93) rather than between WHO and Naranjo scales (k = 0.78). Time consumed for assigning categories was least with Karch and Lasagna scale and maximum with Naranjo Scale. Conclusion: The results of present study propose the site specific use of scale for causality assessment of ADR. Karch and Lasagna scale can be used in resource poor settings like out-patient department and for preliminary assessment while WHO and Naranjo scale can be used in resource intensive settings. Training of physicians, pharmacovigilance associates in periphery and those based at coordination centres should be customised accordingly.

Keywords: ADR, Karch and Lasagna scale.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )