EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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Abstract

CORRELATION BETWEEN APOB/APOAI RATIO AND DYSLIPIDEMIA IN INDIAN CHRONIC HEART FAILURE PATIENTS

Dr. Rohit Sane, Dr. Gurudatta Amin, Dr. Snehal Dongre and *Dr. Rahul Mandole

ABSTRACT

Background: Ratio of apolipoprotein-B (apoB) and apolipoprotein-AI (apoAI) is found to be a strong predictor for cardiovascular diseases, including chronic heart failure (CHF). The debatable relationship between apoB/apoAI and other lipid parameters has not been explored in Indian CHF patients. Hence, we evaluated the correlation between apoB/apoAI and lipid parameters in Indian CHF patients. Methodology: This retrospective study was conducted using data of CHF patients who visited Madhavbaug clinics in India, between July-December 2018. The parameters assessed under lipid profile on the collected venous blood from patients included serum total cholesterol (TC), serum triglycerides (TG), serum low-density lipoproteins (LDL), serum high-density lipoproteins (HDL), serum very-low density lipoproteins (VLDL), serum apoAI and apoB. The apoB/apoAI ratio was calculated and then correlation with other lipid parameters was assessed using Pearson correlation coefficient test. Results: Of the 147 included CHF patients, majority were males (N=109,74.15%) with a mean age of 59.15+10.28 years. The correlation coefficient (R) was found to be 0.41 and 0.24 respectively between apoB/apoAI ratio and serum TC as well as apoB/apoAI ratio and serum TG, which were statistically significant (p<0.05). Correlation between apoB/apoAI ratio and serum HDL was found to be indicative of inverse correlation, but this was not significant statistically (p>0.05). Correlation between apoB/apoAI ratio and serum LDL (R=0.39), serum VLDL (R=0.24) as well as LDL/HDL ratio (R=0.25) were all found to be positive and these findings were statistically significant (p<0.05). Conclusion: Raised apoB/apoAI ratio was found to be significantly correlated with dyslipidemia in the Indian CHF patients.

Keywords: Dyslipidemia, Apolipoprotein B, Apolipoprotein AI, Lipoproteins, Chronic Heart Failure.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )