RNA-NANOPARTICAL IN CANCER THERAPY: PROGRESS AND CHALLENGES
Abhishek Jain*, Sanjay Sharma, Shirish Deshpande, Pritam Jain, Mahesh Kamalja
Currently a popular era in Nano medicine is the implementation of RNA nanoparticles for cancer diagnosis. RNA interference (RNAi) is after-transcriptional gene regulating mechanism where Coding, non-coding takes place. This technology is powerful technology to diagnose and treat diseases. The article endeavors to highlight to clarification of the mechanism of siRNA with concern to possible applications which are established on cancer therapy, and to discuss the possible effectiveness of nanoparticle on the basis of delivery system. Self-assembled nanoparticle (NP) is developed and it competently delivers to small interfering RNA (siRNA) by intravenously to the tumor. The nanoparticle was found by mixing with siRNA, carrier, DNA, and lipids, preceded by after-change. Newly FDA appreciation of the first polymer drug and additional ones in the clinical linked RNA polymer has to be highly therapeutic and diagnostic value. It has been established to be a particular useful means for cell-type definite delivery of other RNA therapeutics like siRNA. While RNAi has helped speed up the discovery and understanding functions of gene, it also has great potential as a therapeutic and potentially prophylactic modality. This article stated about the development in the RNA polymer and also provides some examples of their diagnostic applications and therapeutics.
Keywords: SiRNA Nanoparticle, Cancer therapy & Treatment, RNA, Drug Delivery.
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