( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57



M. Ruzibakieva*, T. Aripova, Z. Azizova, U. Yuldasev, P. Sultanov, D. Sadikov


Chronic glomerulonephritis (CG), chronic renal failure (CRF) are the majority of instances to end stage renal disease (ESRD) which is the cause of renal replacement therapy. It was noted that patients with chronic kidney disease have a greater inflammatory response compared with healthy people. As is generally known, inflammation is partly regulated by the genes of the interleukin-1 (IL-1) gene cluster. We supposed that some single nucleotide polymorphisms (SNPs) in this gene cluster may be associated with the risk of development of CG and ESRD. We have studied polymorphisms in the IL-1 gene cluster in a group of patients with CG and ESRD (n=74) and 66 controls. These individuals were genotyped for 3 single nucleotide polymorphisms in the IL-1beta genes - IL-1beta- 31T/C, -511T/C, 3953C/T SNPs. It was found out, that IL-1beta- 31T and -511 T, TT are associated with CG and ESRD in Uzbeks. At the analysis of haplotype combinations two haplotypes of the IL-1 gene 31T/C, -511T/C, 3953C/T SNPs are associated with ESRD -31T/-511C/3953T and -31C/-511T/3953T. These findings are playing an important role in the study of associations between IL1 SNPs genotype and CG and ESRD in Uzbeks, and shows that polymorphisms in the IL-1 gene cluster affect the risk of development of ESRD.

Keywords: Chronic Renal Failure CRF, CKD, ESRD, Glomerulonephritis, IL1.

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia