EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

PHYTOCHEMICAL SCREENING AND ANTIDIABETIC ACTIVITY OF AQUEOUS METHANOL FRUIT EXTRACT OF SARCOCEPHALUS LATIFOLIUS (SMITH) BRUCE (RUBIACEAE)

Hananiya Hamza Milagawanda*, Yesufu Braimah Hassan and Wazis Chama Haruna

ABSTRACT

Diabetes mellitus is associated with complications and the present treatment is expensive and not readily available. It is also associated with unwanted side effects. WHO recommend the use of medicinal plants in the treatment of several ailments. Sarcocephalus latifolius happens to be one of such plants which have been reported to possess anti-malarial and anti-bacteria effect. However, the use of this plant in the management of diabetics mellitus has not yet been established. Therefore, this study was embarked upon in order to evaluate the anti-diabetic activity of the aqueous fruit extract of Sarcocephalus latifolius. S. latifolius fruit was subjected to standard techniques for extraction, screening for phyto-constituents, acute toxicity testing and anti-diabetic evaluation. The extract tested positive for alkaloid, carbohydrate, glycoside, saponin and terpenoid. The extract was found to possess hypoglycaemic effect that was not dose dependent. At 48 hours of extract administration, the extract was found to reduce hyperglycaemia significantly than insulin (p<0.05) used as the control drug. The fruit extract of Sarcocephalus latifolius contains bioactive phytochemical compounds which may be responsible for the observed hypoglycaemic effect and thus amply justifies the traditional use of this plant.

Keywords: Sarcocephalus Latifolius, Phyto-Constituents, Acute Toxicity, Alloxan, Hypoglycaemia.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )