EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

IN VITRO ANTIDIABETIC ACTIVITY OF METHANOLIC EXTRACTS OF SELECTED MARINE ALGAE

Murugesan S., Anand Babu M., Bhuvaneswari S., Kotteswari M. and Dr. Thennarasan S.*

ABSTRACT

Diabetes mellitus is a chronic disease, which occurs when the pancreas does not produce enough insulin. Marine algae are one of the richest sources of structurally diverse natural products and possess different biological activities. In the present study, three marine algae such as Ulva lactuca, Grateloupia lithophila and Stoechospermum marginatum, were investigated for their antidiabetic potential using in vitro enzyme inhibitory assays. Among these G. lithophila shows the highest IC50 value against α-amylase (IC50 427 μg/mL) and U. lactuca shows the highest IC50 value against α-glucosidase (IC50760 μg/mL), whereas Acarbose, the positive control shows lesser inhibition against the selected marine algae. This study reveals the possible mechanisms of antidiabetic action in vitro. So the further investigation of the antidiabetic activity and identifies the hyperglycemic effect to elucidate their mode of action.

Keywords: Ulva lactuca, Grateloupia lithophila and Stoechospermum marginatum,?-amylase, ?-glucosidase, antidiabetic.

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