EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

A VALIDATED HPLC METHOD FOR DETERMINATION OF TIOCONAZOLE LOADED VAGINAL IMPLANTS PREPARED BY HOT MELT EXTRUSION

Betül Rumeysa Temel, Seda Rençber and I??k Özgüney*

ABSTRACT

Vaginal candidiasis is a common mucosal infection of vagina, mainly caused by Candida species. Tioconazole is an imidazole derivative which is therapeutically used as an antifungal drug. At present study, Tioconazole loaded vaginal implant was prepared using hot melt extrusion method. The routine control analysis of Tioconazole requires rapid, reliable, accurate and precise method for the quantification of the drug in vaginal implant formulation. A simple, rapid and precise reverse phase high performance liquid chromatographic (HPLC) method has been developed for the simultaneous determination of Tioconazole. The method was validated according to ICH guidelines. Validation parameters were linearity, specificity, accuracy, precision (repeatability and reproducibility), limit of detection, limit of quantification and short term stability. Under the optimum reaction conditions, linear relationships with appreciable correlation coefficient (0.9999) were found at 224 nm and the concentration of Tioconazole in the range of 0.5-160 μg/mL.

Keywords: Hot melt extrusion, HPLC method, PLGA, Tioconazole, vaginal implant.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )