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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Muhammad Waqas*, Umar Saeed, Saman Saeed, Shoaib Asif, Arif Malik and Rabbia Tariq


Objective: Assessment of upstream levels of lipid peroxidation and DNA damage regulating the development of rheumatoid arthritis. Study design: Cross sectional comparative study. Place and duration of study: The study was carried out in the institute of molecular biology and biotechnology (IMBB) in The University of Lahore-Pakistan since last two years. Material and methods: Blood, saliva and synovial fluid samples of 75 individuals diagnosed with Rheumatoid Arthritis were collected from Jinnah Hospital Lahore while the samples of 75 normal individual were served as a control. Levels of MDA were determined spectrophotometrically while the concentrations of isoprostanes, 8-OHdG and HNE were measured from commercially available Elisa Kit. Results: Significantly high level of oxidative stress markers were recorded in serum, saliva and synovial fluid of rheumatoid arthritis patients as compared to control. Levels of lipid peroxidation products including MDA (μmol/ml), isoprostanes(pg/ml) and HNE (μmol/ml) and DNA damage in the form of 8-OHdG (pg/ml) were recorded significantly high (p<0.015, p<0.022, p<0.004 and p<0.036 respectively) in rheumatoid Arthritis patients as relative to the normal individuals. Levels of MDA in serum (1.95±0.094/0.95±0.019), saliva (0.012±0.0034/0.056±0.0056) and synovial fluid (3.26±0.65/0.019±0.0016) were differed significantly in both groups. Level of isoprostanes in serum (12.26±5.26/1.26±0.015), saliva (2.16±0.019/0.816±0.017) and synovial fluid (34.26±4.26/0.136±0.019) were recorded higher in RA patients as compared to control. Concentrations of 8-OHdG in serum (0.945±0.014/0.019±0.0035) saliva (0.0024±0.0003/0.0029±0.00017) and synovial fluid (1.33±0.451/0.055±0.0016) were recorded high in RA patients. Significantly high concentration of HNE in serum (4.265±1.25/1.99±0.016), saliva (1.26±0.15/0.191±0.0091) and synovial fluid (6.35±1.16/0.094±0.00165) were recorded in RA diagnosed group relative to control. Conclusion: Oxidative stress biomarkers including lipid peroxidation products contribute to the onset of inflammation and autoimmunity in RA patients.

Keywords: Oxidative Stress, RA, lipid peroxidation, MDA, isoprostane, 8-OHdG, HNE.

[Full Text Article]



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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database