EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

EVALUATION OF ALCOHOLIC EXTRACTS OF SESAMUM INDICUM L. SEEDS COLLECTED FROM PUNJAB REGION OF PAKISTAN ON WOUND HEALING AND SKIN REGENERATION IN RATS.

Sheraz Khan*, Saniya Hashim Khan, Taimur Ali and Narmeen Hashim

ABSTRACT

The aim of this study is to confirm and compare the wound healing effects of sesame oil on experimentally induced excision wound, incision wound, and burn wound models in rats. Sesame oil obtained from different methods of extraction was applied on induced excision wound, incision wound and burn wound models in 5 groups of Sprague-Dawly rats. Each group had 6 rats. Group I-III were topically treated with 2ml of various and pure extracts of sesame oil. Group IV was treated with the standard treatment of Aloe vera extract (10% gel formulation) while Group V received no treatment for 25 days. In incision wound model, ANOVA and Dunnett's test were applied (P < 0.05) to compare relative wound area. For excision and burn wound models, the wound contraction-50% (days) was determined by plotting the wound area vs days on a graph paper. Comparatively, noticeable decrease in wound length and increased epithelialization period was observed in incision wound model and better rate of closure was found in sesame oil groups (P < 0.05). In the burn and excision wound models, significant reduction (P<0.001) in wound contraction (50%) and epithelialization period was also noted in sesame oil groups. Overall, an improved healing pattern was found in rats who received various extracts of sesame oil corresponding to standard treatment while sesame oil extract of ethyl acetate was found to have highest potential for wound healing than other extracts. The findings showed that sesame oil extract of ethyl acetate has much better potential for wound healing and skin regeneration in rats.

Keywords: Excision, Incision, Burns, Sesamum indicum, Wound healing, Epithelialization.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )