EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

HEPATO-PROTECTIVE POTENTIALS OF TEPHROSIA LINEARIS (WILLD.) PERS EXTRACT ON ACETOMINOPHEN INDUCED HEPATO TOXICITY IN WISTAR ALBINO RATS

Garba M. H.*, Ampitan A. T., Halidu S. K. and Omotugba S. K.

ABSTRACT

The main thrust of the study was investigate the proctective potentials of stem bark extract of Tephrosia linearis in acetaminophen induced hepatotoxicity in experimental animals. Thirty experimental animals (Wistar rats) were grouped into six. Groups I and II were the placebo and the standard group respectively. Group III were the negative treatments hepato-toxified by sub chronic oral administration of acetaminophen at a dosage of 250 mg/kgbw daily for three consecutive days. Groups IV, V and VI were hepato-toxified as in III and thereafter, followed up with treatment with 70% methanol stem bark extract of Tephrosia linearis at a dosage of 200, 400 and 600 mg/Kgbw on daily basis for three weeks (21 days). There was significant decrease (P≤ 0.05) in both haematological and serum biochemical parameters of induced animals compared to the placebo and standard treatment at the onset of the treatment. Thereafter a significant increase (P≤ 0.05) was observed in the HB, PCV, MCV, RBC and TWBC with a corresponding decrease ((P≤ 0.05) in the platelets count in the groups treated. Similarly, significant increase (P≤ 0.05) in the serum AST, ALT, ALP, Total protein, direct and indirect biluribin and ICDH with a concomitant decrease ((P≤ 0.05) in GDH was also observed in the treated groups compared to the negative control. The inadequacy of herbs used in curing of liver diseases and other dysfunctions caused by allopathic drugs is enough reason to focus on systematic scientific research to evaluate some species of plants that are traditionally claimed to possess hepato-curative activities.

Keywords: Acetominophen, Hepatotoxicity, Sub-chronic, Tephrosia linearis, Haematological indices, Biochemical indices, CYP450 enzymes, Wistar Albino rats.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )