EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

LONG-TERM CONSUMPTION OF COCONUT OIL DIET EXACERBATES PAIN AND INFLAMMATION IN CD1 MICE

*Bisong S. A., Ita S. O., Mfem C. C., Nku-Ekpang O. T. and Eteng B. B.

ABSTRACT

The effect of long-term coconut oil diet on pain in CD1 mice was studied. Thirty (30) CD1 mice weighing 16.5g to 22.6g were randomly assigned into three groups. Mice in group A (control group; n=10) were given the normal rodent chow (Vital Feed) while mice in group B (low dose; n=10) and group C (high dose; n=10) were fed 5% and 20% coconut oil diets respectively for 4 weeks. Thereafter, the animals were assessed for pain and inflammation using the formalin test. The results showed that the frequency and duration of paw lick was significantly higher in the 20% diet group compared to control and 5% diet groups during acute and chronic phases of the formalin test (P< 0.05). The frequency of paw flinch was also higher in the 20% diet group compared to control and the 5% diet groups (p<0.05) in both phases of the test. The change in anteroposterior and mediolateral diameters of the paws were also significantly greater in the 20% coconut oil diet group when compared to control. The frequency of line crossed was also reduced due to the pain and inflammation showing immobility in the mice. Therefore, these result imply that the 20% coconut oil diet increase pain perception and inflammation in the mice, although the 5% diet caused a minimal effect when compared to the 20% diet.

Keywords: Coconut oil, pain, mice.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )